Copper peptide creams

Products & techniques


Copper peptide cream

Are you interested in a treatment that replaces damaged, scarred or wrinkled skin with fresh new skin?

What are copper peptide creams?

Copper peptides are present in the human body including in the skin. They are probably a biochemical feedback signal generated after tissue injury. They are a tissue protective, anti-inflammatory agent that limits oxidative damage and is also used as a signal to activate tissue remodeling, that is, a signal to remove damaged tissue and replace it with normal tissue.. In cell cultures, copper peptide acts directly, in a dose dependent manner, on fibroblasts by increasing the production of m-RNA and protein formation of collagen, elastin, proteoglycans, glycosaminoglycans and decorin. [Mostly from Dr Loren Pickart's site]

Copper peptides, skin repair and collagen.

Skin remodeling is the removal of proteins and older cells from the skin. This means removing scars, and wrinkles while smoothing the skin. Increasing skin remodeling is the key to producing a biologically younger skin.

Skin remodeling happens all the time in young people, but it declines rapidly after we reach twenty years old. Copper peptide creams increase skin remodeling and so reduce wrinkles, sun damage, skin tags, certain types of moles and age spots, old stretch marks and burn scars. Usually these are reduced with the combination of copper-peptide creams and glycolic acid creams but often the copper peptides are effective alone. The method produces no skin irritation and results are usually evident in one month although maximum effects often require longer.

There activity of skin cells is controlled by signals from the surrounding skin tissue - when certain peptides are freed and copper peptides do seem to activate this process. During aging, skin proteins accumulate damage from many causes - sun damage, cross-linking by sugars, free radical injuries and so on. Recent research has established that copper-peptide complexes are potent activators of the metalloproteinases (Simeon et al 1999 and Simeon et al 2000) that work in skin remodeling.

The metalloproteinases are a family of at least 14 proteins that remove other damaged proteins such as damaged collagen and elastin. The old damaged protein is removed and replaced with new collagen and elastin fibers. This removes scar tissue and restores skin elasticity and reduces wrinkles. The activation of such proteins may explain the potent scar reduction properties of copper peptide creams.

Copper-peptides increase the skin's regenerative processes - as well as speeding up the removal of damaged protein and stimulating skin renewal (either with or without peels and lasers) - so they can help skin renewal after exfoliation or various skin resurfacing treatments.

Copper peptides also enhance the skin's natural regenerative responses by helping stimulate new capillary formation (angiogenesis), increasing the production of collagen, elastin and the water-holding proteoglycans and glycosaminoglycans.

Copper peptide creams used for scar reduction.

Copper peptides, along with exfoliating " target="_blank">hydroxy acids, are a good way to reduce scars. The hydroxy acids (glycolic acid 14% to 30%, but other hydroxy acids should work) are combined with copper peptide cream and rubbed into the scar once or twice daily. The scar should reduce in a month but 6 to 8 months of application may be necessary to reach a satisfactory appearance in very old scars (30 to 50 year old scars or stretch marks). While this method is slow, it is cheap and will not cause further scarring.

This method depends on the hydroxy acids to dissolve a very small amount of the scar, stretch mark, or mole daily, while the copper peptides repair the skin. Possibly the copper peptide cream activates metalloproteinases and suppresses of the production of the scar producing growth factor TGF-beta1. It appears that, used properly, normal skin will replace the slowly-dissolving skin blemishes.

Wheres the science?

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

"Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide with affinity for copper(II) ions and was isolated from human plasma. This peptide appears to play a physiological role in wound healing. We report the stimulating effect of GHK-Cu [copper peptides] on collagen synthesis by fibroblasts. The stimulation began between 10(-12) and 10(-11) M, maximized at 10(-9) M, and was independent of any change in cell number. The presence of a GHK trIPLet in the alpha 2(I) chain of type I collagen suggests that the tripeptide might be liberated by proteases at the site of a wound and exert in situ healing effects."